Sterling Malory Archer (voiced by John Benjamin) codename "Duchess" is the world's most dangerous spy, a womanizer, and probably an alcoholic on Archer. "I'm scared that if I stop [drinking] all at once, the cumulative hangover will kill me." ~ Archer
Uni the Unicorn (below, left) is a Bobby's (kind of annoying) companion in the Dungeons & Dragons cartoon.
Zetan (played by the great Christopher Lee) was the keeper of a book that contained all the world's wisdom in Circle of Iron (a.k.a. The Silent Flute). "Release me, Cord! Release me..." ~ Zetan to Cord the Seeker
Cheryl David - played by Cheryl Hines, she pokes and prods but somehow tolerates Larry David's idionsycracies on Curb Your Enthusiasm
Dominique Derval (a.k.a. Domino), played by Claudine Auger, is the "niece" of Emilo Largo in Thunderball. Domino is my all-time favorite Bond girl. She's young, intelligent, sexually aggressive, funny, beautiful, bitter, and a realist . She is also one of the few Bond girls to both save Bond's life, and kill the villain. "I understand you're Mr. Largo's niece." ~ James Bond "Sounds better than -what would you say?- kept woman, mistress?" ~ Domino "I wouldn't say that." ~ James Bond
Harry Dresden (played by Paul Blackthorne) is a wizard/private investigator in the unfortunately short-lived Sci-Fi adaptation of Jim Butcher's The Dresden Files. "Harry Dresden - Wizard. Lost Items Found. Paranormal Investigations. Consulting. Advice. Reasonable Rates." ~ Sign on Harry Dresden's Office
Jules Winfield (played by Samuel L. Jackson) is an associate of Marsellus Wallace in Pulp Fiction. Jules witnesses a freak occurrence (maybe even a miracle) and decides to leave his life of crime behind him. "Normally, both your asses would be dead as fucking fried chicken, but you happen to pull this shit while I'm in a transitional period so I don't wanna kill you, I wanna help you. But I can't give you this case, it don't belong to me. Besides, I've already been through too much shit this morning over this case to hand it over to your dumb ass. " ~ Jules Winfield to Ringo
Quelaag - this half woman/half spider demon is a boss character in From Software's classic Dark Souls
Seath the Scaleless - Seath double-crossed his peers and helped the Gods eliminate the dragon race to welcome in the Age of Fire in Dark Souls
Walter Sobchak - John Goodman plays a bowling obsessed lunatic helping his friend The Dude investigate a kidnapping.